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Welcome to the Evidence Based Treatment Centers of Seattle

The Evidence Based Treatment Centers of Seattle (EBTCS), PLLC is a network of specialty mental health centers united by a central mission: to deliver state-of-the-art, evidence-based psychological treatments with genuine compassion and care. We believe it is our responsibility to stay up to date with current research and advances in our field, so that when people entrust us with their care, we can confidently say that we are providing treatments that have the best science behind them. We also believe that people learn and grow best when they are in an environment of genuine compassion and support. Science and compassion: it’s a simple formula and one that is at the core of everything we do. It is also what has made EBTCS a leader in our community for over a decade.

How do we do it? We regularly meet as a community to keep our training and education up to date. We meet weekly as treatment teams to help each other maintain our high standards of excellence and to think creatively about how to apply evidence-based treatments in ways that meet the needs of each individual. We track our clients’ outcomes over the course of treatment so we can evaluate whether what we are doing is working. And we conduct our own practice-based research to contribute to the ever evolving science of mental health care. In short, we work hard to make sure that those who seek our services get the very best care we can provide.

EBTCS is home to four specialty centers. These include: the Dialectical Behavior Therapy (DBT) Center , the Anxiety Center , the Child Anxiety Center , and the Tahari Womens TaEsther Pump Black Ra6IWIF
. Click to learn more about the EBTCS story and evidence-based treatment .

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BMC Bioinformatics 2014 15 :79

https://doi.org/10.1186/1471-2105-15-79

© Clark et al.; licensee BioMed Central Ltd.2014

Received: 21November2013

Accepted: 11March2014

Published: 21March2014

Abstract

Background

Identifying differentially expressed genes (DEG) is a fundamental step in studies that perform genome wide expression profiling. Typically, DEG are identified by univariate approaches such as Significance Analysis of Microarrays (SAM) or Linear Models for Microarray Data (LIMMA) for processing cDNA microarrays, and differential gene expression analysis based on the negative binomial distribution (DESeq) or Empirical analysis of Digital Gene Expression data in R (edgeR) for RNA-seq profiling.

Results

Here we present a new geometrical multivariate approach to identify DEG called the Characteristic Direction. We demonstrate that the Characteristic Direction method is significantly more sensitive than existing methods for identifying DEG in the context of transcription factor (TF) and drug perturbation responses over a large number of microarray experiments. We also benchmarked the Characteristic Direction method using synthetic data, as well as RNA-Seq data. A large collection of microarray expression data from TF perturbations (73 experiments) and drug perturbations (130 experiments) extracted from the Gene Expression Omnibus (GEO), as well as an RNA-Seq study that profiled genome-wide gene expression and STAT3 DNA binding in two subtypes of diffuse large B-cell Lymphoma, were used for benchmarking the method using real data. ChIP-Seq data identifying DNA binding sites of the perturbed TFs, as well as known drug targets of the perturbing drugs, were used as prior knowledge silver-standard for validation. In all cases the Characteristic Direction DEG calling method outperformed other methods. We find that when drugs are applied to cells in various contexts, the proteins that interact with the drug-targets are differentially expressed and more of the corresponding genes are discovered by the Characteristic Direction method. In addition, we show that the Characteristic Direction conceptualization can be used to perform improved gene set enrichment analyses when compared with the gene-set enrichment analysis (GSEA) and the hypergeometric test.

Conclusions

The application of the Characteristic Direction method may shed new light on relevant biological mechanisms that would have remained undiscovered by the current state-of-the-art DEG methods. The method is freely accessible via various open source code implementations using four popular programming languages: R, Python, MATLAB and Mathematica, all available at: http://www.maayanlab.net/CD .

Gene Ontology Synthetic Data Differentially Express Gene Characteristic Direction Random Subspace

Genome-wide transcriptional profiling, the parallel measurement of the expression of tens of thousands of genes, is a powerful tool which, for example, aids in the development of clinical biomarkers for disease diagnosis, reveals the heterogeneity of histologically identical cancers, and sheds light on diverse biological mechanisms. After estimating the relative or absolute expression level of all transcripts, the next step is to test statistical hypotheses [ 1 ]. Typically, these hypotheses are concerned with the difference between two biological conditions, for example, normal verses diseased tissue, or perturbed verses unperturbed cells. One of the most important aims of such tests is to identify the genes which are mostly responsible for the difference between the biological states under investigation, the so called differentially expressed genes (DEG).

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A Signature Welcome is a gifting company, curating gifts that celebrate™. Founded in 2014 by Lindsay Marko and Emily Slater in Charleston, South Carolina, A Signature Welcome offers gifting services to all domestic and international clients looking for individual or group gifts.

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Lindsay Marko and Emily Slater of A Signature Welcome know how to make a great first impression- even on each other. They became fast friends in 2003while attending The University of Georgia. Ten years later, both moved to Charleston with a vision. Emily, a wedding magazine veteran and Lindsay, a graduate of New York City’s Parsons The New School for Design and Jimmy Fallon costumes alum, were ready to combine strengths and begin their gifting company, curating gifts that celebrate™.

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Gifts are personal and make an impression. Through our custom process, work one-on-one with our design team to create gifts exclusive to you. Your dedicated designers will take time to learn about your event details and your gifting needs. Together you will establish a design concept and overall color story to create a one-of-a-kind gifting experience. We take great care in designing bespoke gifts inspired by your vision.

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Martha Stewart Weddings Spring 2018

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Martha Stewart Real Weddings and Honeymoons Fall 2017

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“Working with the team at A Signature Welcome was an effortless venture! As an interior designer, I have very high standards for how design elements work together, and my wedding was no exception. I worked with their team to incorporate my custom artwork into the labels of the items in my welcome boxes. Our guests loved the welcome gifts so much, and many of them posted their welcome gifts on social media when they arrived in Nashville because they were beautifully picturesque and “Instagram worthy.”

Margaret Waltemath Ash

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